Perthshire businesses are feeling less confident because of Brexit, according to the council.
Half a million pensioners will be forced to seek private healthcare or miss out on an enhanced flu jab because of a national shortage, MSPs have been told.
NHS Tayside is the country's slowest health board at treating people for alcohol and drug problems.
The Tay Cities Deal faces a funding threat with the UK Government cutting its contribution to the £1 billion investment package.
Rail travel could be too expensive for thousands more Scots when new price rises kick in next year, Labour have said.