Residents and businesses say road closures are causing chaos in Lochee with emergency vehicles now getting caught in the snarl up.
Tayside Contracts is carrying out upgrade works on the High Street and has closed a number of roads.
But a lack of clear signage and drivers heading down dead-ends is creating bedlam.
Resident James O’Neil said he believes it is only a matter of time before the road closures cause a serious accident.
Cars are turning left from Camperdown Street down Methven Street only to find the road is blocked.
Some are then turning up Bright Street, even though it is one way.
Those that don’t are forced to do a three-point turn as traffic heading the right way down Bright Street comes down onto Methven Street
He said: “There are even taxis going the wrong way up Bright Street.
“This can’t go on for a month. There’s going to be a head-on collision. Somebody is going to end up in a wheelchair.
“The council says there are going to be monitoring the situation but I haven’t seen anyone doing it.”
Meanwhile, traders on the High Street say their businesses are losing out because the entire street has been closed to traffic.
Habib Syed, who runs the post office in his Mace store on Lochee High Street, said the closure had caused severe problems for his business.
He said: “It has been closed all week, the entire street. We are suffering. Sales are down 75% but we cannot close as the post office is a public service.
“All the High Street is dying here.
“Everywhere else is closed and no one except us is open.
“This is the first time it has happened for a full week. I am really worried about my business.
“I received a letter saying it would be closed about a week before it started.
“I think they should have closed one side of the road and then the other. At least businesses would have got some relief that way. Having it closed for a full week is very difficult and a lot of pressure.
“People are put off coming to Lochee because of the one way roads and narrow turns – it makes it very difficult for us.
“It seems to be Lochee that is always targeted. I don’t know why.”
Councillor Tam Ferguson, who has described the roadworks as “Piccadilly Circus”, said he warned planners the diversion would cause issues.
He said: “I predicted this would be a problem for them one to two weeks before they got there. I gave them prior warning and no one listened.”
Mr Ferguson was left further frustrated after a fire engine and car ended up battling for space on Bright Street.
He said: “Where are the emergency service vehicles going to go? A member of the public told me he had seen an ambulance getting stuck at the top end.
“I was exasperated when I went to see it for myself the other day. This should all have been ironed out before the work was started.”
A spokesman for the Scottish Fire and Rescue Service said a unit had visited to provide advice on “domestic flooding”.
A Dundee City Council spokeswoman said: “Dundee City Council is continuing to focus on these works.”