The A92 was closed in the Mearns after one person was left trapped inside their car.
The injured man was taken to hospital after being cut free.
The crash took place four miles north of Inverbervie and both lanes of the carriageway are currently closed.
A police spokeswoman said: “We received the call just after 4pm to a two-vehicle crash on the A92 heading in the direction of Kinneff.”
The extent of the man’s injuries are not known.