An engraved iPad and two charity boxes were stolen during a break-in at the ARCHIE Foundation’s charity shop in the Wellgate.
The raid took place some time between 4pm on Friday and 3pm on Sunday.
It is thought a two figure sum of money was taken from the charity boxes.
Anyone with any information which may be useful should contact Tayside Division on 101 quoting reference number CR/3815/17.
Information can also be passed to any police officer or anonymously via the charity Crimestoppers on 0800 555 111.
A spokesperson for The ARCHIE Foundation said: ”We have had wonderful support from the people of Tayside as we raise money for the Tayside Children’s Hospital appeal and our staff and volunteers have worked tirelessly in the shop, so we are shocked and saddened that this break-in has occurred.
“Fortunately there is little of value left in the shop overnight but we will be closed on Monday while we clear up.
“We will be open again from Tuesday and look forward to welcoming our supporters as usual,” they added.
The shop moved to the Wellgate from Dundee’s Overgate centre and among the popular items on sale there were miniature versions of some of the Oor Wullie statues which captured the imagination of visitors to Dundee and beyond during last year’s Bucket Trail initiative.