Five school campuses in Perth and Kinross will reopen on Thursday morning for children of Category One key workers.
The activity centres will run throughout the week and over the weekend if needed.
They could even continue during the Easter holidays, which officially begin early next month.
Parents who have been allocated places were due to be contacted by 5pm on Wednesday.
The hubs will run at North Inch Campus, Kinross Primary School, the Community School of Auchterarder, Newhill Campus in Blairgowrie and Invergowrie Primary School.
Each centre will teach children in small groups, in order to reduce the risk of infection, and siblings will be kept together.
Several nurseries and registered childminders will also be providing spaces for youngsters over the coming weeks, but only those who have been offered spaces can attend.
Category One workers are described as frontline health and care workers directly tackling the coronavirus outbreak.
Executive director of education Sheena Devlin said: “Our Children’s Activities Centres will provide additional capacity to the childcare we have been providing this week and will help ensure essential workers can continue their valuable work over the coming weeks.
“We appreciate this is a difficult time for our young people and their parents and carers and we would like to thank them all for their patience and understanding.”
The Scottish Government ordered all schools to close at the end of last week, but teachers were told to return to class on Monday morning.
They were stood down on Sunday evening, while the council finalised its plan for activity centres.
Meanwhile, the local authority has decided against providing meals from school buildings.
Families entitled to free school meals will instead get the equivalent amount paid into their accounts. The first payments will go out this week, and are expected to continue throughout the Easter break.