The route to the Champions League final will be settled on Friday for the eight sides left competing for continental glory.
Seedings and country protection are no more as we enter the quarter-final draw in Nyon, Switzerland, where the semi-finals will also be decided.
Ahead of the draw, Press Association Sport takes a look at the eight remaining sides.
Coach: Erik ten Hag
Star man: Dusan Tadic
Champions League best: Winner x 4 (1971, 1972, 1973 and 1995)
The Dutch giants are looking forward to their first Champions League quarter-final in 16 years after roaring past Real Madrid so impressively.
Coach: Ernesto Valverde
Star man: Lionel Messi
Champions League best: Winners x 5 (1992, 2006, 2009, 2011 and 2015)
The Messi-inspired La Liga winners are dreaming of a treble, although they have not made it past the quarter-final stage since last winning the Champions League in 2015.
Coach: Massimiliano Allegri
Star man: Cristiano Ronaldo
Champions League best: Winners x 2 (1985 and 1996)
The perennial Serie A winners have Champions League glory in their sights after big-name summer signing Ronaldo produced a hat-trick to overturn 2019 final hosts Atletico Madrid in midweek.
Coach: Jurgen Klopp
Star man: Sadio Mane
Champions League best: Winner x 5 (1977, 1978, 1981, 1984 and 2005)
Battling it out with Manchester City for the Premier League crown, last season’s Champions League runners-up will be confident of kicking on after winning at German giants Bayern Munich on Wednesday.
Coach: Pep Guardiola
Star man: Sergio Aguero
Champions League best: Semi-finals (2016)
One of two sides left in the competition not to have being crowned champions of Europe, there are plenty of reasons why Guardiola’s swashbuckling side are favourites to lift the trophy.
Coach: Ole Gunnar Solskjaer (caretaker)
Star man: Paul Pogba
Champions League best: Winners x 3 (1968, 1999 and 2008)
Jose Mourinho started United’s campaign and inspired interim choice Solskjaer will finish it, having overseen a historic comeback win at Paris St Germain in the round of 16.
Coach: Sergio Conceicao
Star man: Eder Militao
Champions League best: Winners x 2 (1987 and 2004)
A surprise name in the quarter-final draw, Porto sealed their place in the last eight for the first time in four years by shocking last season’s semi-finalists Roma.
Coach: Mauricio Pochettino
Star man: Harry Kane
Champions League best: Semi-finals (1962)
Despite failing to make a signing or move into their new stadium on time, Spurs have performed impressively this term and dispatched highly-rated Borussia Dortmund in the last 16.