Leeds crushed rock-bottom Stoke 3-0 at the Bet365 Stadium to retain their place at the top of the Sky Bet Championship and pile further pressure on manager Nathan Jones.
Patrick Van Aanholt struck in stoppage time to give Crystal Palace their first league win at Old Trafford since 1989 as they beat Manchester United 2-1.
Managerless Bolton suffered another defeat as they were ruthlessly beaten 5-0 at home to Ipswich in front of a record low attendance.
QPR came from behind to beat Wigan 3-1 and clinch their first home league win under boss Mark Warburton.
Bristol City claimed a third Sky Bet Championship victory in a row with a 3-1 win over Hull at the KCOM Stadium.
Managerless Huddersfield’s winless run in all competitions stretched to 16 games as they lost 2-0 at home to Reading.
Harvey Barnes’ spectacular second-half thunderbolt clinched Leicester a 2-1 win at Sheffield United and their first victory of the season.
England issued a powerful statement ahead of the World Cup by overwhelming Ireland 57-15 at Twickenham in a victory that set records for highest score and greatest winning margin against their Six Nations rivals.
Moussa Djenepo’s stunning first Premier League goal set Southampton on course for their first points of the season as they won 2-0 at 10-man Brighton.
Rock-bottom Ebbsfleet picked up their first point of the season after twice fighting back to draw 2-2 with Notts County.