Cluj will be hoping to capitalise on a depleted Celtic side in their Europa League Group E clash and secure qualification for the knockout stage.
The Scottish club are already through at the top of the table, but will not be at full strength for the trip to Romania.
Dan Petrescu’s men can also book their place in the last 32 with victory or a draw, and if qualification rivals Lazio fail to win.
Celtic captain Scott Brown must serve a suspension, while right-back Jeremie Frimpong is not registered for European competition.
With Group E already won, Hoops boss Neil Lennon will take the opportunity to rest some other players amid a busy fixture schedule, which follows on from the Betfred Cup victory over Rangers.
There could be possible debuts for 18-year-old midfielder Scott Robertson and defender Grant Savoury, 19, along with a first European appearance for 16-year-old forward Karamoko Dembele.