Cambridge midfielder Paul Digby is set to miss out again when Scunthorpe visit the Abbey in Sky Bet League Two.
Digby has missed the last six matches with a foot injury and is still not quite ready to return.
The Us’ were boosted by the returns of Wes Hoolahan and Hiram Boateng for the 1-0 win over Port Vale at the weekend.
Boateng got 69 minutes under his belt following his first action since December.
Scunthorpe have a host of new injury concerns while George Taft is ruled out.
Defender Taft came off early in Saturday’s home game against Cheltenham with an ankle injury which could result in a long spell out.
Striker Ryan Loft was also withdrawn at half-time with a groin problem and will be assessed.
There will also be fitness checks for Emmanuel Onariase and Abo Eisa.