Colchester boss Hayden Mullins will check on Freddie Sears and Armando Dobra ahead of Saturday’s League Two clash with Barrow.
The pair missed Tuesday night’s 2-0 defeat at Forest Green through illness and will be assessed.
Wimbledon striker Corie Andrews made his debut in that game after completing a loan move, while defender Tom Dallison was an unused substitute following his switch from Crawley.
Mullins’ Covid-hit team have lost their last four games in all competitions and are without a win in six.
Barrow will be without midfielder Tom Beadling through suspension after last Saturday’s eventful FA Cup third-round defeat at Sky Bet Championship Barnsley.
Beadling was sent off before half-time during the 5-4 extra-time defeat at Oakwell for a challenge on Romal Palmer and must sit out as a result.
Sunderland loanee Will Harris could be handed a debut after missing out against the Tykes due to a positive Covid test, and Jacob Wakeling will hope for a place in the matchday squad following his arrival on loan from Leicester.
Midfielder Robbie Gotts has a chance of returning after a groin problem, but Joe Grayson and Josh Gordon are long-term absentees and Offrande Zanzala has joined Exeter on loan.