The A911 was closed for over three hours after a three-vehicle crash near Milton of Balgonie.
Emergency services were scrambled to the Fife road at around 4pm on Sunday.
The Scottish Fire and Rescue Service (SFRS) confirmed the occupants of the vehicles were able to get themselves out safely.
They then went into the care of paramedics, an SFRS spokeswoman advised.
The extent of their injuries is not known.
Police were managing traffic at the scene before the road reopened shortly after 7pm.
Police Scotland has been approached for comment.