The road between Blairgowrie and Bridge of Cally following a motorbike crash.
The one-vehicle incident happened on the A93, near to Mains of Mause cottage, shortly before 4.50pm.
A spokesman for Police Scotland said one man had been taken to hospital and the road remains closed for investigations to take place.
RTC A93 at Mains of Mause Farm, Blairgowrie. Road closed. Police in attendance. Diversions in place.
— Perth&KinrossCouncil (@PerthandKinross) October 12, 2017
The road reopened shortly before 7.30pm.