The crash happened in Ballingry just after 5.30pm on Friday.
Emergency services, including Scottish Fire and Rescue Service and Police Scotland went to the scene.
It is not yet known if there are any casualties.
Crash in Ballingry in Fife
A Police Scotland spokesperson said: “Around 5.35pm on Friday, 18 August we were called to a report of a crash involving a car and a motorcycle on Benarty Square in Ballingry.
“Emergency services, including Police Scottish and Scottish Fire and Rescue Service attended.”
Scottish Fire and Rescue Service spokesperson said: “We received a report about a crash involving a car and motorbike in Benarty Square in Ballingry.
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